Buy Actavis Levothyroxine T4 28 x 100mcg

Actavis Levothyroxine T4 28 x 100mcg
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LEVOTHYROXINE TABLETS BP 100 micrograms

Each tablet contains 100 micrograms anhydrous Levothyroxine Sodium.

White uncoated tablets. White, circular, shallow convex uncoated tablets impressed “C” on one face and the identifying letters “TC” on the reverse.

Recommended clinical indications:

1. control of hypothyroidism,

2. congenital hypothyroidism in infants

3. acquired hypothyroidism in children

4. juvenile myxoedema.

4.2 Posology and method of administration

Posology

It is recommended that the tablets should be administered before breakfast or your first meal of the day.

Adults: Initially 50-100 micrograms daily, then adjusted at 3-4 week intervals by 50 microgram increments until normal metabolism is steadily maintained. This may require doses of up to 100-200 micrograms daily.

Patients over 50 years:

It is not advisable to exceed 50 micrograms a day initially. The dose may then be increased by 50 micrograms every 3-4 weeks until thyroxine levels are correct. A final dose is between 50-200 micrograms daily.

In younger patients, and in the absence of heart disease, a serum levothyroxine (T4) level of approximately 70-160 nanomoles/litre or a serum thyrotrophin level of less than 5 milli-units/litre should be aimed at. In those aged over 50, and/or in the presence of heart disease, clinical response is probably a more acceptable criterion of dosage than serum levels.

A pre-therapy ECG is valuable, as changes induced by hypothyroidism may be confused with ECG evidence of ischaemia. If too rapid an increase of metabolism is produced, dosage should be reduced or withheld for a day or two, then recommenced at a lower level.

Patients over 50 years with heart disease:

Where there is cardiac disease, 25 micrograms daily, or 50 micrograms on alternate days is more suitable. In this condition the daily dosage may be increased by 25 microgram increments at intervals of maybe 4 weeks. A final dose is between 50-200 micrograms daily.

Paediatric patients:

The maintenance dose is generally 100 to 150micrograms per m² body surface area. For neonates and infants with congenital hypothyroidism, where rapid replacement is important, the initial recommended dosage is 10 to 15micrograms per kg BW per day for the first 3 months. Thereafter, the dose should be adjusted individually according to the clinical findings and thyroid hormone and TSH values.

For children with acquired hypothyroidism, the initial recommended dosage is 12.5-50micrograms per day. The dose should be increased gradually every 2 to 4 weeks according to the clinical findings and thyroid hormone and TSH values until the full replacement dose is reached. Infants should be given the total daily dose at least half an hour before the first meal of the day.

Juvenile myxoedema: A suitable starting dose is 25micrograms levothyroxine daily, with increments of 25micrograms every 2-4 weeks until mild toxic symptoms appear. Dosage should then be slightly reduced. The starting dose for children older than one year may be 2.5-5micrograms/kg bodyweight daily.

When applicable:

Tablets are to be disintegrated in some water (10 to 15ml) and the resultant suspension, which must be prepared freshly as required, is to be administered with some more liquid (5 to 10ml).

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